Troponin T and N-Terminal Pro–B-Type Natriuretic Peptide: A Biomarker Approach to Predict Heart Failure Risk—The Atherosclerosis Risk in Communities Study

9,868 participants without prevalent heart failure from the Atherosclerosis Risk in Communities (ARIC) study

Addition of high-sensitivity cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) to risk prediction models

Standard risk prediction models (age and race alone, or the ARIC HF model which includes age, race, systolic blood pressure, antihypertensive medication use, current/former smoking, diabetes, body mass index, prevalent coronary heart disease, and heart rate)

Incident heart failure risk prediction (measured by area under the receiver operating characteristic curve [AUC], integrated discrimination improvement, net reclassification improvement [NRI], and model fit) over a mean follow-up of 10.4 yearshard clinical