Key result
SCAD primarily affects women and is linked to FMD in ~1% of AMIs.
Spontaneous coronary-artery dissection is a rare cause of acute myocardial infarction predominantly affecting middle-aged women, often associated with fibromuscular dysplasia, and typically managed medically.
Warrants SCAD consideration in middle-aged women with AMI; leaves open prospective evaluation of FMD links and management.
Coronary-artery dissections account for less than 1% of acute myocardial infarctions, occur most commonly in women and most often between the ages of 47 and 53 years, may be associated with an underlying disorder such as fibromuscular dysplasia and other noncoronary arterial abnormalities, and are usually treated medically.
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Esther Kim (2020) studied this question. Spontaneous coronary-artery dissection, primarily affecting women aged 47-53, is associated with fibromuscular dysplasia in less than 1% of acute myocardial infarctions.
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