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The research aims to explore the expression levels of PLK1 in lung adenocarcinoma and its clinical implications.

January 17, 2026PeerJOpen Access

PLK1 overexpression as a dual-role biomarker and therapeutic vulnerability in pulmonary adenocarcinoma

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The research aims to explore the expression levels of PLK1 in lung adenocarcinoma and its clinical implications.
Utilized data from TCGA, GEO, and GTEx to analyze PLK1 expression in LUAD.
Employed statistical methods including Wilcoxon rank-sum test and logistic regression.
Conducted survival analyses using Kaplan-Meier and COX regression methods.
Validated findings through immunohistochemical staining and in vitro experiments.
PLK1 was significantly elevated in LUAD tissues compared to normal tissues.
High PLK1 expression correlated with advanced tumor stages and poorer overall survival.
Functional analyses indicated involvement of PLK1 in cell cycle regulation.
Inhibition of PLK1 in A549 cells reduced cell proliferation and increased apoptosis.

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This analysis investigates PLK1's role as a biomarker and therapeutic target in lung adenocarcinoma, suggesting its clinical significance.

You et al. (2026) studied this question.

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This analysis investigates PLK1's role as a biomarker and therapeutic target in lung adenocarcinoma, suggesting its clinical significance.