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This study aims to evaluate how social determinants of health affect overall survival in AML patients under ELN 2022 criteria.

January 17, 2026Blood AdvancesOpen Access

Stratifying Survival: The Role of Social Determinants of Health on AML Outcomes by ELN 2022 Criteria

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Analysis reveals social determinants of health influence outcomes in acute myeloid leukemia, highlighting intervention opportunities.

This study aims to evaluate how social determinants of health affect overall survival in AML patients under ELN 2022 criteria.
Evaluated 365 patients newly diagnosed with AML treated with intensive chemotherapy.
Measured social determinants of health using the national Area Deprivation Index categorized as high or low.
Assessed overall survival in different ELN risk categories: favorable, adverse, and intermediate.
Conducted multivariable analyses adjusted for age, race, sex, and transplantation.
Overall survival was similar for high and low nADI groups in favorable and adverse risk groups.
In the intermediate risk group, overall survival was significantly higher in the more advantaged group (median 33 vs. 17 months, p=0.04).
Survival advantage seemed mediated by a higher relapse rate among less advantaged patients post-transplant.

Shimony et al. (2026) studied this question.

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