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January 17, 2026Pediatric ResearchOpen Access

Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics

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Authors

IWIsabella L. C. Mariani WigleyALAlexandra LautarescuEVElena Vartiainen

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Overview

Investigates how maternal prenatal BMI affects neonatal brain dynamics, showing implications for neurodevelopmental outcomes.

Key Points

  • This research aims to explore the relationship between maternal pre-pregnancy BMI, perinatal depressive symptoms, and neonatal brain network dynamics.
  • Utilized functional MRI and Leading Eigenvector Analysis (LEiDA) on a neonatal cohort
  • Sample consisted of 437 neonates from the developing Human Connectome Project
  • Measured maternal BMI categories and perinatal depressive symptoms using the Edinburgh Postnatal Depression Scale
  • Assessed associations between brain-state probabilities, BMI, and EPDS scores
  • Analyzed interaction effects between maternal BMI and depressive symptoms.
  • EPDS scores did not correlate with neonatal brain states or show significant interaction effects with BMI
  • Higher pre-pregnancy BMI negatively affected the stability of a key functional brain network (ß = −0.129, p = 0.006)
  • Demonstrated that increased maternal BMI is linked to slower maturation of frontal, parietal, and temporal brain systems
  • Findings indicate selective impacts of maternal metabolic health on neonatal brain organization.

Cite This Study

Wigley et al. (2026) studied this question.

synapsesocial.com/papers/696b26d7d2a12237a934a0a1https://doi.org/10.1038/s41390-025-04726-2
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