Key result
Multimodality imaging confirms recurrent Tako-Tsubo syndrome in an 80-year-old woman after ruling out significant CAD.
This case highlights the importance of multimodality imaging, including CCT, ICA, and CMR, in accurately diagnosing Tako-Tsubo syndrome recurrence and ruling out acute coronary syndrome.
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Multimodality imaging may aid recurrent TTS diagnosis after CAD exclusion; single case report leaves open need for validation.
We report the case of an 80 yo female patient with cardiovascular risk factors and previous diagnosis of Tako-Tsubo syndrome, who was referred to our institution one year after a previous diagnosis, due to symptoms suggestive of acute coronary syndrome (SCA) after severe emotional stress. After ruling out suspected CAD by cardiac computed tomography (CCT) and subsequent invasive coronary angiography (ICA) confirming no significant stenosis but presence of vulnerable plaque, the patient underwent further investigation by cardiac magnetic resonance (CMR) that confirmed a clinical picture compatible with recurrence of Tako-Tsubo syndrome. Our case underlines the importance of multimodality imaging to guide diagnosis and treatment in this specific clinical scenario.
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Berloni et al. (2026) studied this question. Multimodality imaging confirmed recurrence of Tako-Tsubo syndrome in an 80-year-old female after ruling out significant CAD with conventional methods.
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