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The study aims to compare the prediction accuracy of AlphaFold and ESMFold for both monomeric and dimeric proteins.

Comparative evaluation of the prediction accuracy of AlphaFold and ESMFold for monomeric and dimeric proteins

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This evaluation compares AlphaFold and ESMFold's accuracy in predicting protein structures, indicating varying effectiveness for monomers and dimers.

The study aims to compare the prediction accuracy of AlphaFold and ESMFold for both monomeric and dimeric proteins.
Evaluated prediction accuracy of AlphaFold2, AlphaFold3, and ESMFold using structures from the Protein Data Bank.
Selected 1666 monomeric and 994 dimeric proteins based on specific criteria for benchmarking.
Analyzed the prediction results against experimentally derived structures.
AlphaFold2 and AlphaFold3 accurately predicted 88% of monomeric structures and 77% of dimeric proteins.
ESMFold correctly predicted 76% of monomeric proteins and 41% of dimeric proteins.
Accuracy increased to 95% for monomeric proteins when excluding certain structure types.

Mahtha et al. (2026) studied this question.

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This evaluation compares AlphaFold and ESMFold's accuracy in predicting protein structures, indicating varying effectiveness for monomers and dimers.