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To synthesize and characterize zinc(II) complexes with benzothiazolyl azo compounds and evaluate their biological properties.

Zinc(II) Complexes with Benzothiazolyl Azo Compounds: Synthesis, Structural Characterization, NIR Emission, and Biological Properties

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To synthesize and characterize zinc(II) complexes with benzothiazolyl azo compounds and evaluate their biological properties.
Synthesis of four benzothiazolyl azo ligands and their zinc(II) complexes
Characterization using mass spectroscopy, FTIR, NMR, and UV-vis
Study of photophysical properties through electronic and luminescent spectra
Assessment of antimicrobial activity against S. aureus
Evaluation of cytotoxicity against HepG-2 and A549 cell lines
Zinc(II) complexes exhibited near-infrared emission at 690–900 nm.
All zinc(II) chelates demonstrated effective antimicrobial activity against S. aureus.
All prepared azo compounds showed promising antitumor activity against cancer cells with IC50 values < 50 µg/mL.
Benzothiazolyl azo ligands had better antitumor potential for HepG-2 than A549, while zinc(II) complexes had better activity for A549 than HepG-2.

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Synthesizes zinc complexes and evaluates their biological activities, suggesting potential uses in medicine.

Nguyen et al. (2026) studied this question.

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