Descriptive analysis uncovers prescribing variations and links SCS use to increased adverse outcomes in CRSwNP patients, suggesting the need for better guidelines.
Key Points
The aim is to investigate dispensing patterns of systemic corticosteroids in patients with chronic rhinosinusitis with nasal polyps and their associated adverse outcomes.
Analyzed pharmacy claims from CRSwNP patients
Descriptive study on prescribing practices among healthcare providers
Employed multinomial logistic regression to assess factors of SCS use
Used time to event regression analysis for associations with adverse outcomes
Higher rates of SCS dispensing found among patients in rural areas
Increased risk of pneumonia, hypertension, and cardio/cerebrovascular disease in SCS users
Dose-response relationship not clearly observed; risks linked to cumulative SCS doses