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January 20, 2026BMC Infectious DiseasesOpen Access

Systemic inflammation response index predicts short-term mortality in intensive care unit patients with bacterial bloodstream infections

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Authors

AVAslı VatanSESalih EmreGBGokcen Gurkok Budak

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Overview

Retrospective study shows systemic inflammation response index predicts 14-day mortality in ICU patients with bloodstream infections, indicating a need for improved risk stratification.

Key Points

  • Evaluate the prognostic value of systemic inflammation response index in predicting mortality in ICU patients with bloodstream infections.
  • Retrospective study of 199 adult patients with bloodstream infections at Sakarya University Hospital from 2018-2022.
  • Calculated systemic inflammation response index and other clinical parameters at BSI onset.
  • Used receiver operating characteristic to determine optimal cut-off SIRI for mortality prediction.
  • Conducted multivariate regression analysis to examine correlation between mortality and SIRI.
  • Median SIRI value at BSI onset was 5003.
  • Higher SIRI levels associated with increased risk of 14-day (p=0.001) and 30-day (p=0.011) mortality.
  • SIRI ≥ 5003 independently predicted 14-day mortality (p=0.02).
  • Logistic regression showed higher initial CRP, elevated neutrophil counts, and presence of COVID-19 or malignancy increased mortality risk.

Cite This Study

Vatan et al. (2026) studied this question.

synapsesocial.com/papers/696ed06d6d8d470fca57abbbhttps://doi.org/10.1186/s12879-026-12552-y
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