Key result
High systemic inflammation response index linked to ~15% higher 28-day mortality risk in sepsis.
Why the study?
This study evaluated the association and prognostic significance of the systemic inflammation response index (SIRI) with mortality in sepsis.
Does a high systemic inflammation response index (SIRI) predict mortality in patients with sepsis?
Population
4239 sepsis patients from MIMIC-III and MIMIC-IV ICU databases
Comparison
High SIRI levels vs lower SIRI levels
Design
Cohort study
Follow-up
1-year
Authors
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SIRI may refine mortality risk stratification in sepsis; leaves open whether it guides therapy or improves outcomes.
Cohort (n=4,239)
Does a high systemic inflammation response index (SIRI) predict mortality in patients with sepsis?
Hazard Ratio: 1.15 (95% CI 1.03–1.29)
p-value: p=.010
Elevated systemic inflammation response index (SIRI) is an independent prognostic biomarker associated with increased short- and long-term mortality in patients with sepsis.
Ru et al. (2023) conducted a cohort in sepsis (n=4,239). Systemic inflammation response index (SIRI) vs. Lower SIRI levels was evaluated on 28-day mortality (HR 1.15, 95% CI 1.03-1.29, p=.010). High systemic inflammation response index levels were associated with an increased risk of 28-day mortality in patients with sepsis (HR 1.15; 95% CI 1.03-1.29; P=0.010).
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