What question did this study set out to answer?

The research aims to evaluate how sample size affects cluster-extent thresholds in fMRI analysis and reduce type II error.

January 20, 2026

Reducing type II error in fMRI analysis: cluster-extent threshold simulation results and an evaluation of current methods to correct for multiple comparisons.

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Authors

SSScott D. SlotnickBoston College

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Implication

Simulation study evaluates the effect of sample size on cluster thresholds in fMRI analysis, suggesting improved accuracy in correcting multiple comparisons.

Key Points

The research aims to evaluate how sample size affects cluster-extent thresholds in fMRI analysis and reduce type II error.
Conducted simulations varying sample sizes (N: 10, 20, 30) and various p-values.
Fixed acquisition volume parameters while testing individual-voxel p-values and FWHM.
Performed 100 iterations of each simulation, totaling 4,860,000 iterations.
Applied Bayesian analysis to evaluate the significance of findings.
Clusters were approximately 18% smaller when sample size was modeled compared to when it was not.
Larger sample sizes resulted in significantly increased cluster thresholds.
Bayesian analysis strongly supported the hypothesis regarding the effect of sample size.

Cite This Study

Scott D. Slotnick (2026) studied this question.

synapsesocial.com/papers/696f1a239e64f732b51ee755 https://doi.org/10.1080/17588928.2026.2615960

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Implication

Simulation study evaluates the effect of sample size on cluster thresholds in fMRI analysis, suggesting improved accuracy in correcting multiple comparisons.

Reducing type II error in fMRI analysis: cluster-extent threshold simulation results and an evaluation of current methods to correct for multiple comparisons.

Discussion

Member takes

Implication

Key Points

Cite This Study

Reducing type II error in fMRI analysis: cluster-extent threshold simulation results and an evaluation of current methods to correct for multiple comparisons.

Discussion

Member takes

Implication

Key Points

Cite This Study

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