Haemodynamic definitions and updated clinical classification of pulmonary hypertension
Key result
6th WSPH defines pre-capillary PH as mPAP >20 mmHg with PVR ≥3 Wood Units.
Why the study?
The historic definition of pulmonary hypertension was arbitrary, prompting the 6th WSPH Task Force to update haemodynamic definitions based on normal subject data and revise the clinical classification.
Design
Task Force consensus report
Authors
Discussion
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Implication
Challenges longstanding mPAP ≥25 mmHg threshold; leaves open effects on outcomes and management.
Key Points
- This paper aims to redefine pulmonary hypertension based on newer scientific data and improve clinical classification.
- Reevaluation of mPAP threshold for defining pulmonary hypertension based on normal subject data.
- Introduction of pulmonary vascular resistance as a criterion for pre-capillary pulmonary hypertension.
- Proposed classification changes for pulmonary arterial hypertension subcategories.
- At rest, normal mPAP is determined to be 14.0±3.3 mmHg.
- A mPAP >20 mmHg and pulmonary vascular resistance ≥3 Wood Units are critical for defining pre-capillary pulmonary hypertension.
- New subgroups in classification improve the management of patients with specific pulmonary arterial hypertension responses.
Cite This Study
Simonneau et al. (2018) studied this question. The 6th WSPH Task Force suggests defining pre-capillary pulmonary hypertension as mPAP >20 mmHg with pulmonary vascular resistance ≥3 Wood Units.