Synthesis and binding studies of two new coumarin-squaramide-based receptors for NSAIDs

Luca Mancini; Filippo Ingargiola; Giampaolo Barone; Patrizia Rossi; Mauro Formica; Eleonora Macedi; Martina Lippi; Luca Giorgi; Luca Prodi; Vieri Fusi; Daniele Paderni

doi:10.1039/d5ra08698a

January 1, 2026RSC AdvancesOpen Access

Synthesis and binding studies of two new coumarin-squaramide-based receptors for NSAIDs

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Key Points

The aim is to synthesize and characterize new squaramide-based receptors for nonsteroidal anti-inflammatory drugs (NSAIDs).
Synthesis of coumarin-squaramide receptors
Characterization in solution and solid state
Analysis of binding interactions with NSAID anions via H-bonding
The new receptors effectively interact with NSAID anions
H-bonding occurs between squaramide and carboxylate groups
Characterization confirms the structural properties of the receptors

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Implication

New squaramide receptors bind NSAIDs through H-bonding interactions, suggesting potential for drug design.

Abstract

New squaramide-based receptors for NSAIDs bearing coumarin units have been synthesized and characterized in solution and solid state, revealing able to interact with the guest anions via H-bonding between squaramide and carboxylate functions.

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Cite This Study

Mancini et al. (2026) studied this question.

synapsesocial.com/papers/69706c09b6488063ad5c16af https://doi.org/10.1039/d5ra08698a

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Synthesis and binding studies of two new coumarin-squaramide-based receptors for NSAIDs

Key Points

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Implication

Abstract

Discussion

Cite This Study

Synthesis and binding studies of two new coumarin-squaramide-based receptors for NSAIDs

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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