What question did this study set out to answer?

The aim is to synthesize and characterize new squaramide-based receptors for nonsteroidal anti-inflammatory drugs (NSAIDs).

January 21, 2026RSC Advances0 citationsOpen Access

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Synthesis and binding studies of two new coumarin-squaramide-based receptors for NSAIDs

LMLuca ManciniUniversity of Urbino FIFilippo IngargiolaUniversity of Bologna GBGiampaolo BaroneUniversity of Palermo

Key Points

The aim is to synthesize and characterize new squaramide-based receptors for nonsteroidal anti-inflammatory drugs (NSAIDs).
Synthesis of coumarin-squaramide receptors
Characterization in solution and solid state
Analysis of binding interactions with NSAID anions via H-bonding
The new receptors effectively interact with NSAID anions
H-bonding occurs between squaramide and carboxylate groups
Characterization confirms the structural properties of the receptors

Abstract

New squaramide-based receptors for NSAIDs bearing coumarin units have been synthesized and characterized in solution and solid state, revealing able to interact with the guest anions via H-bonding between squaramide and carboxylate functions.

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Synthesis and binding studies of two new coumarin-squaramide-based receptors for NSAIDs

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Abstract

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