What question did this study set out to answer?

The primary aim is to explore the inhibitory effects of a new nor-28-oleanane glycoside on nitric oxide production.

January 21, 2026

A new nor-28-oleanane glycoside isolated from Syzygium formosum inhibits nitric oxide production in LPS-stimulated RAW264.7 cells

PTPham Thi ThamHanoi University of Industry PGPham Thi Thu GiangHanoi University of Industry LHLai Thi HuyenHanoi University of Industry

Puntos clave

The primary aim is to explore the inhibitory effects of a new nor-28-oleanane glycoside on nitric oxide production.
Isolated compounds from methanol extract of Syzygium formosum leaves.
Utilized HRESIMS and NMR for structural elucidation.
Determined absolute configuration using ECD spectra and TD-DFT methods.
Assessed nitric oxide production in LPS-stimulated RAW264.7 cells.
Syringin demonstrated significant inhibitory activity against NO production with an IC50 of 18.4 μM.
Compounds 1-3 showed moderate inhibitory effects with IC50 values ranging from 58.4-79.2 μM.

Resumen

One new nor-28-oleanane glycoside (1) and fifteen known compounds (2 - 16) were separated from a methanol extract of Syzygium formosum leaves. Their structures were elucidated via HRESIMS and NMR spectroscopic analyses. The absolute configuration of 1 was determined based on ECD spectra calculated using TD-DFT methods. Among the isolates, syringin (11) exhibited significant inhibitory activity against NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 18.4 μM. Compounds 1 - 3 displayed moderate inhibitory effects, with IC50 values of 58.4-79.2 μM.

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