Prospective Assessment of the Diagnostic Accuracy of Instantaneous Wave-Free Ratio to Assess Coronary Stenosis Relevance
Key result
iFR shows diagnostic value for assessing coronary stenoses and complements FFR in a hybrid approach.
Why the study?
Does instantaneous wave-free ratio (iFR) accurately assess the functional significance of coronary stenoses compared to FFR?
Population
Patients with coronary stenoses
Comparison
Instantaneous Wave-Free Ratio (iFR) vs Fractional Flow Reserve (FFR)
Design
Cohort
Authors
Discussion
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Member takes
Implication
iFR may complement FFR in hybrid stenosis assessment; leaves open human validation before practice change.
Key Points
- To prospectively evaluate the diagnostic accuracy of the instantaneous wave-free ratio (iFR) in determining the functional significance of coronary artery stenoses.
- Prospective interventional evaluation conducted within the ADVISE II study framework (NCT01740895).
- Assessed the standalone diagnostic performance of iFR alongside a combined hybrid iFR-FFR (fractional flow reserve) diagnostic protocol.
- iFR demonstrated robust diagnostic value for establishing the functional hemodynamic significance of coronary artery lesions.
- The hybrid iFR-FFR strategy exhibited high clinical complementarity, optimizing lesion evaluation while reducing the requirement for vasodilator administration.
Structured PICO
Does instantaneous wave-free ratio (iFR) accurately assess the functional significance of coronary stenoses compared to FFR?
P
Population
Patients with coronary stenoses
I
Intervention
Instantaneous Wave-Free Ratio (iFR)
C
Comparator
Fractional Flow Reserve (FFR)
O
Outcome
Diagnostic accuracy in establishing the functional significance of coronary stenosessurrogate
iFR demonstrates diagnostic value for assessing the functional significance of coronary stenoses and is complementary to FFR in a hybrid approach.
Cite This Study
Escaned et al. (2015) studied this question. The iFR was found to have diagnostic value for assessing the functional significance of coronary stenoses, complementing FFR in a hybrid approach.