Key result
Left bundle branch block causes relative rather than absolute septal underperfusion during exercise, attributed to relative lateral hyperperfusion.
Why the study?
Does right ventricular pacing induce relative septal underperfusion similar to left bundle branch block?
Does right ventricular pacing induce relative septal underperfusion similar to left bundle branch block?
Septal perfusion defects in LBBB represent a functional relative lateral hyperperfusion rather than an absolute structural decrease in septal flow.
RV pacing may induce similar relative septal underperfusion as LBBB; leaves open clinical relevance pending prospective validation.
The apparent septal perfusion defect in LBBB is mainly due to a relative lateral hyperperfusion rather than to an absolute septal flow decrease. This pattern seems to be reversibly inducible by right ventricular pacing, suggesting a functional rather than a structural alteration.
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Koepfli et al. (2009) studied this question. Left bundle branch block causes relative rather than absolute septal underperfusion during exercise, attributed to relative lateral hyperperfusion.
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