Tandem Electrophilic Thiocyanation/Cyclization of α-Alkynyl Oximes for Synthesis of 4-Thiocyanatoisoxazoles

Key Points

• This research aims to develop an efficient method for synthesizing thiocyanato-containing isoxazole derivatives through tandem reactions.
• Conducted tandem electrophilic thiocyanation followed by cyclization under mild conditions.
• Utilized 1,3-diphenyl-2-propyn-1-one O-methyloxime as the starting material.
• Searched for optimized conditions to increase yield.
• Achieved moderate to excellent yields for a series of thiocyanato isoxazole derivatives.
• Demonstrated the feasibility of the tandem process in synthesis.