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The research aims to evaluate naphthoquinone-derived organometallics for their cytotoxic effects and stability.

January 22, 2026Dalton Transactions0 citationsOpen Access

Naphthoquinone-derived tridentate Ru( ii ) and Os( ii ) organometallics with exceptional cytotoxicity: synthesis, characterization, stability in aqueous solution and biological in vitro evaluation

ARAlexander RosnerUniversity of Vienna HGHeiko GeislerUniversity of Vienna MHMichaela HejlUniversity of Vienna

Key Points

The research aims to evaluate naphthoquinone-derived organometallics for their cytotoxic effects and stability.
Synthesis of N, O, O-tridentate complexes with various alkyl groups.
Assessment of stability in aqueous solutions.
Biological evaluation through cytotoxicity and cellular accumulation studies.
Analysis of effects on cell cycle dynamics and IDO inhibition.
Certain organometallic complexes exhibited significant cytotoxicity against various cell lines.
Stability in aqueous solutions varied with different alkyl substituents.
Some complexes demonstrated notable cellular accumulation and impact on cell cycle progression.
IDO inhibition was effectively observed, suggesting a potential therapeutic mechanism.

Abstract

A panel of organometallic N , O , O -tridentate complexes bearing different alkyl substituents is presented. The impact on stability in aqueous systems, cytotoxicity, cellular accumulation, cell cycle and IDO inhibition is discussed.

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