Modular synthesis of sulfilimines via NFSI-mediated S-arylation of sulfenamides with naphthols, phenols and indoles †

Fucong Dong; He Liu; Xiaodong Xiong

doi:10.1039/d5ob01861g

January 1, 2025Organic & Biomolecular Chemistry

Modular synthesis of sulfilimines via NFSI-mediated S-arylation of sulfenamides with naphthols, phenols and indoles †

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Key Points

The central aim is to establish an efficient and modular approach for synthesizing sulfilimines.
Used NFSI as a reagent for S-arylation of sulfenamides.
Utilized naphthols, phenols, and indoles as coupling partners.
Conducted a modular synthesis to facilitate structural diversity.
Successfully synthesized various sulfilimine derivatives.
Demonstrated the method's efficiency and versatility in organic synthesis.

Implication

Demonstrates a new method for synthesizing sulfilimines in organic synthesis, suggesting broader applications in medicinal chemistry.

Abstract

Sulfilimines were exploited as valuable moieties in organic synthesis and medicinal chemistry, however, efficient methods for constructing such scaffolds remain limited. Herein, we disclosed a convenient method for modular synthesis...

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Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/6971bd6a642b1836717e2273 https://doi.org/10.1039/d5ob01861g

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Modular synthesis of sulfilimines via NFSI-mediated S-arylation of sulfenamides with naphthols, phenols and indoles †

Key Points

Implication

Abstract

Discussion

Cite This Study

Modular synthesis of sulfilimines via NFSI-mediated S-arylation of sulfenamides with naphthols, phenols and indoles †

Key Points

Implication

Abstract

Discussion

Cite This Study

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