A Lung-Targeted Self-Assembled Supramolecular nanofiber for Synergistic Therapy of Idiopathic Pulmonary Fibrosis

Jiaxi Han; Taotian Zhang; Yilin Jiang; Tianyuan Chen; Jiawei Lu; Zhenkang Diao; Qing Lin; Shiqi Huang; Ling Zhang

doi:10.1039/d5nr04194e

January 1, 2026Nanoscale

A Lung-Targeted Self-Assembled Supramolecular nanofiber for Synergistic Therapy of Idiopathic Pulmonary Fibrosis

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Key Points

This research aims to develop a lung-targeted nanofiber system for more effective treatment of idiopathic pulmonary fibrosis.
Creation of a self-assembled supramolecular nanofiber.
Evaluation of nintedanib delivery mechanisms.
Assessment of therapeutic efficacy in reducing pulmonary fibrosis.
The supramolecular nanofiber enhanced the delivery of nintedanib to lung tissues.
Combination therapy showed improved fibrosis reduction compared to nintedanib alone.
Significant improvements were observed in lung function metrics.

Implication

A lung-targeted supramolecular nanofiber improves outcomes in idiopathic pulmonary fibrosis, suggesting a new therapeutic approach.

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options and high mortality rates. As an FDA-approved tyrosine kinase inhibitor, nintedanib (BIBF) effectively renders pulmonary fibrosis...

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Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/6971bd90642b1836717e245d https://doi.org/10.1039/d5nr04194e

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A Lung-Targeted Self-Assembled Supramolecular nanofiber for Synergistic Therapy of Idiopathic Pulmonary Fibrosis

Key Points

Implication

Abstract

Discussion

Cite This Study

A Lung-Targeted Self-Assembled Supramolecular nanofiber for Synergistic Therapy of Idiopathic Pulmonary Fibrosis

Key Points

Implication

Abstract

Discussion

Cite This Study

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