A Lung-Targeted Self-Assembled Supramolecular nanofiber for Synergistic Therapy of Idiopathic Pulmonary Fibrosis

Key Points

• This research aims to develop a lung-targeted nanofiber system for more effective treatment of idiopathic pulmonary fibrosis.
• Creation of a self-assembled supramolecular nanofiber.
• Evaluation of nintedanib delivery mechanisms.
• Assessment of therapeutic efficacy in reducing pulmonary fibrosis.
• The supramolecular nanofiber enhanced the delivery of nintedanib to lung tissues.
• Combination therapy showed improved fibrosis reduction compared to nintedanib alone.
• Significant improvements were observed in lung function metrics.