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January 22, 2026Organic & Biomolecular Chemistry0 citations

Electrochemical Synthesis of 2-Substituted Quinazolinones from Primary Benzylic C(sp3)–H bonds and 2-Aminobenzamides

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ZLzirong liuZYzhongqi yangLYLeilei Ye

Key Points

  • The research aims to develop an electrochemical method for synthesizing quinazolinones from primary benzylic C(sp3)–H bonds.
  • Utilized electrochemical conditions for synthesis
  • Employed primary benzylic C(sp3)–H bonds
  • Performed dehydrogenative cascade cyclization
  • Avoided external chemical oxidants
  • Successfully synthesized 2-substituted quinazolinones
  • Achieved reactions under undivided electrolytic conditions
  • No reliance on external oxidants indicated increased efficiency

Abstract

An electrochemical promoted primary benzylic C(sp3)–H directive dehydrogenative cascade cyclization for the synthesis of quinazolinones has been developed under undivided electrolytic conditions. In this protocol, neither external chemical oxidants nor...

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Cite This Study

liu et al. (2025) studied this question.

synapsesocial.com/papers/6971bdad642b1836717e2592https://doi.org/10.1039/d5ob01863c
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