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January 22, 2026Journal of ChemometricsOpen Access

Multivariate Optimization of Column Liquid Chromatography for the Separation of Saturated, Aromatic, and Acidic Biomarkers in Petroleum and Rock Extracts

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Authors

ASAlek A. C. de SousaWSWandreson dos S. SousaASAlexandre de Souza

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Overview

Experiments optimize liquid chromatography separation of biomarkers in petroleum and rock extracts, suggesting enhanced analysis efficiency.

Key Points

  • To optimize the separation of saturated, aromatic, and carboxylic acid biomarkers using liquid chromatography modified by Brønsted bases.
  • Applied classical liquid chromatography with modified silica gel phases.
  • Tested sodium and potassium hydroxides as Brønsted bases.
  • Utilized central composite design (CCD) to assess separation efficiency factors.
  • KOH modification showed greater resistance to eluent influence compared to NaOH.
  • Both modifications yielded fractions rich in carboxylic acids.
  • Separation efficiency trend observed as K > Na for saturated and aromatic compounds.
  • Method demonstrates time and material savings for routine analyses.

Cite This Study

Sousa et al. (2026) studied this question.

synapsesocial.com/papers/6971bdcf642b1836717e26a1https://doi.org/10.1002/cem.70102
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