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January 22, 2026mBioOpen Access

Targeting the lung innate pathways during tuberculosis can improve vaccine-induced protection via Th17 responses in diversity outbred mice

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Authors

MAMushtaq AhmedWashington University in St. LouisSDShibali DasWashington University in St. LouisBRB. RosaWashington University in St. Louis

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Implication

Diversity outbred mice vaccinated with BCG show improved TB protection through Th17 responses, suggesting new strategies.

Key Points

  • This research aims to explore how targeting lung innate pathways enhances vaccine-induced protection against tuberculosis in diversity outbred mice.
  • Established tuberculosis model in diversity outbred mice
  • Vaccinated mice with BCG and assessed protection against Mtb
  • Targeted lung innate pathways with adjuvants
  • Depleted CD4 T cells to study their role in protection
  • BCG-vaccinated mice showed significant protection against Mtb infection
  • Increased IL-17-producing CD4 T-cell responses correlated with enhanced protection
  • Induction of pathways related to TGF-β and TLR-10 signaling was observed
  • Depleting CD4 T cells resulted in loss of vaccine-induced protection

Cite This Study

Ahmed et al. (2026) studied this question.

synapsesocial.com/papers/6971bdcf642b1836717e26dfhttps://doi.org/10.1128/mbio.03232-25
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