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August 19, 2025VaccinesOpen Access

BCG Vaccine-Induced Innate and Adaptive Pulmonary Immunity Correlating with Protective Efficacy Against Mycobacterium Tuberculosis in the Lungs

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Authors

MKMayank KhannaARAlistair J. Ramsay

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Overview

Administration of BCG vaccine enhances pulmonary immunity and reduces bacterial loads in a murine model, suggesting valuable immune correlates for protection.

Key Points

  • BCG administered intravenously improved protective immunity against Mycobacterium tuberculosis, showcasing an enhanced immune response.
  • Elevated levels of IFNγ were notably expressed in NK cells and ILC populations within 72 hours of IV vaccination, indicating robust immune activation.
  • Analysis involved fluorescence activated cell sorting and cytokine staining to assess the immune profile in mice vaccinated via different routes.
  • Findings highlight the potential of innate and adaptive immune responses as biomarkers for effective vaccine strategies against Mtb.

Cite This Study

Khanna et al. (2025) studied this question.

synapsesocial.com/papers/68af494dad7bf08b1ead4e8ehttps://doi.org/10.3390/vaccines13080876
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunological mechanistic action of intravenous BCG-mediated protection against tuberculosis2026
  2. 2B69-02 Targeting Lung Tissue Resident Immunity via Intramuscular Vaccination for Protection Against Mycobacterium Tuberculosis2026
  3. 3Intravenous BCG induces a more potent airway and lung immune response than intradermal BCG in SIV-infected macaques2024
  4. 4Time Course Characterization of Protective Immune Responses Following BCG Vaccination in BALB/c Mice2026
  5. 5Intravenous BCG vaccination provides better protection for neonatal mice than for adult mice infected with Mycobacterium tuberculosis 92212025