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April 10, 2026PathogensOpen Access

Time Course Characterization of Protective Immune Responses Following BCG Vaccination in BALB/c Mice

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Authors

HKHo KimKKKwangwook KimMKMinjung Kim

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Overview

Characterizes immune responses after BCG vaccination in BALB/c mice, suggesting monitoring at week 8 for cytokine dynamics.

Key Points

  • The objective is to evaluate time-dependent immune responses to BCG vaccination in BALB/c mice.
  • BALB/c mice were vaccinated with BCG vaccine.
  • Immune responses were evaluated at 4, 6, and 8 weeks post-vaccination.
  • Cytokine expression in serum, lung, and spleen tissues was measured using ELISA, qPCR, and immunohistochemistry.
  • Protective efficacy was assessed using CFU enumeration post-aerosol challenge.
  • Significant increases in pulmonary IL-1β and splenic IFN-γ levels at 4 weeks.
  • Elevated serum IL-2, pulmonary IL-2, and TNF-α levels at 8 weeks.
  • No significant cytokine changes observed at 6 weeks.
  • BCG-vaccinated mice had reduced bacterial burdens after the challenge compared to controls.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69d893406c1944d70ce04438https://doi.org/10.3390/pathogens15040392
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