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November 1, 2025The Journal of ImmunologyOpen Access

Intravenous BCG vaccination provides better protection for neonatal mice than for adult mice infected with Mycobacterium tuberculosis 9221

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Authors

RRRajesh Kumar RadhakrishnanAVAbhinav VankayalapatiODOlamipejo Durojaye

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Overview

Intravenous BCG vaccination enhances immune responses and reduces bacterial burden in neonatal mice, suggesting improved protection against tuberculosis.

Key Points

  • To compare the immune responses and protection provided by IV BCG vaccination in neonatal versus adult mice infected with Mycobacterium tuberculosis.
  • Compared immune responses of IV BCG-vaccinated neonatal and adult mice
  • Measured bacterial burdens in lungs and spleens
  • Analyzed cytokine levels and immune cell populations
  • IV BCG vaccination significantly reduced lung and spleen bacterial burdens in neonatal mice
  • Increased levels of IL-2 in neonatal mice
  • Enhanced immune cell activation in the spleen of neonatal mice

Cite This Study

Radhakrishnan et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc35992bhttps://doi.org/10.1093/jimmun/vkaf283.2650
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1BCG Vaccine-Induced Innate and Adaptive Pulmonary Immunity Correlating with Protective Efficacy Against Mycobacterium Tuberculosis in the Lungs2025 · 1 citations
  2. 2Intravenous BCG induces a more potent airway and lung immune response than intradermal BCG in SIV-infected macaques2024
  3. 3BCG vaccination reduces growth and dissemination rates of Mycobacterium tuberculosis in ultra-low dose-infected mice 29962025
  4. 4BCG vaccination in childhood is not related to pulmonary immunity against <i>M. tuberculosis</i> in adults2014
  5. 5Intravenous Bacillus Calmette–Guérin (BCG) Induces a More Potent Airway and Lung Immune Response than Intradermal BCG in Simian Immunodeficiency Virus–infected Macaques2024 · 7 citations