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March 24, 2026European Respiratory Journal

BCG vaccination in childhood is not related to pulmonary immunity against M. tuberculosis in adults

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Authors

CHChristian HerzmanGSGiovanni SotgiuTSTom Schaberg

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Overview

Evaluation shows no correlation between neonatal BCG vaccination and adult immunity to M. tuberculosis, suggesting reconsideration of its efficacy.

Key Points

  • To assess the impact of neonatal BCG vaccination on adult sensitivity to M. tuberculosis antigens.
  • Recruited adult healthcare workers, household contacts, and cured tuberculosis patients.
  • Conducted interferon-g release assays (IGRAs) on blood and bronchoalveolar-lavage mononuclear cells.
  • Performed growth inhibition assays with co-cultured BALMC and M. tuberculosis.
  • 64% of participants were BCG vaccinated, but no association was found between M. tuberculosis-specific IGRA responses and vaccination.
  • Vaccinated individuals showed more PPD-responsive BAL mononuclear cells compared to non-vaccinated (22 spots vs. 8 spots, P=0.0468).
  • M. tuberculosis growth rates were similar in both vaccinated and non-vaccinated subjects.

Cite This Study

Herzman et al. (2014) studied this question.

synapsesocial.com/papers/69c2296aaeb5a845df0d3dd9https://doi.org/10.1183/13993003/erj.44.suppl_58.4479
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Also Consider

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  5. 5Efficacy, immunogenicity, and safety of BCG revaccination against Mycobacterium tuberculosis: A systematic review and meta-analysis2026 · 3 citations