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Prenatal zygosity testing aids chorionicity assignment in twin pregnancies, indicating potential management benefits.
Based on postpartum placental pathology as the reference standard for determining MC versus DC, cfDNA zygosity testing appears to aid in the prenatal assignment of chorionicity. Larger studies are needed to confirm the value of zygosity testing in the management of twin pregnancies.
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Quintero et al. (2026) studied this question.
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