What question did this study set out to answer?

Evaluate the efficacy of a Tasty&Healthy diet as a maintenance treatment in inducing radiological and endoscopic remission in Crohn’s disease patients.

January 23, 2026

P0951An exclusive whole-food Tasty&Healthy diet induces endoscopic and radiological healing in Crohn’s disease when used as maintenance treatment: results from the MyTasty clinical trial

Key Points

Evaluate the efficacy of a Tasty&Healthy diet as a maintenance treatment in inducing radiological and endoscopic remission in Crohn’s disease patients.
Enrolled patients aged 4–37 years with deep remission from prior trials.
Participants followed the Tasty&Healthy diet for 24 weeks with monthly reintroduction of gluten and dairy.
Fecal calprotectin levels guided dietary adjustments, eliminating gluten or dairy if levels rose beyond 30%.
Intestinal ultrasound and endoscopy assessments were performed at baseline and 24 weeks.
Clinical remission maintained in 37 out of 43 participants (86%).
53% of patients successfully reintroduced gluten and dairy.
All intestinal ultrasound parameters improved significantly from baseline to 24 weeks.
Among 29 patients with follow-up assessments, 86% showed improvement in ileal scores, and 83% showed overall score improvement.
Of 23 patients who underwent endoscopy, 61% exhibited complete healing or minimal ulcers.

Abstract

Abstract Background Tasty no formula or mandatory components are needed. Here we aimed to evaluate whether T8 and wPCDAI12.5/CDAI150) in the previous TASTI-MM (T 30% increase in fecal calprotectin prompted re-elimination of the specific ingredient. Intestinal Ultrasound with Segmental Activity Scoring (IUS-SAS) was performed at weeks 0, 8 and 24 and, in a subset who consented, video capsule-endoscopy (VCE) or ileocolonoscopy at week 24. Results Forty-three patients were enrolled: age 16±5.8 years, 33 children/adolescents; 91% not receiving any therapy besides T 53% successfully re-introduced gluten and dairy. All IUS parameters improved from baseline to weeks 8 and 24 ( including the maximal bowel score (IBUS-SAS 44.9 IQR 2.1-64.9, 14 0-48.5, 13.6 0-34,6; p = 0.0068) and in the terminal ileum (43 IQR 0-64.8, 14 0- 47.5, 5 0-31, respectively; p = 0.0069). Among 29 patients with paired IUS assessments at baseline and week 24, 86% showed improvement or normalization of the ileal IBUS-SAS score, and 83% (24/29) demonstrated improvement in both the maximal and panenteric cumulative scores. Of the 23 patients who underwent VCE/ileocolonoscopy, 14 (61%) exhibited complete endoscopic healing or had only a few aphthous ulcers. Conclusion The T&H diet, combined with structured, calprotectin-guided reintroduction of gluten and dairy, maintained clinical remission and improved radiological and endoscopic inflammation in patients up to 24 weeks. Reference: 1. Aharoni-Frutkoff Y, Plotkin L, Pollak D, et al. Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn’s Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial. Gastroenterology 2025. Conflict of interest: Plotkin, Luba: No conflict of interest Aharoni-Frutkoff, Yonat: No conflict of interest Shavit, Zivia: No conflict of interest Ms. Focht, Gili: No conflict of interest Livovsky, Jessica: No conflict of interest Lev Zion, Raffi: No conflict of interest Ledder, Oren: No conflict of interest Cytter- Kuint, Ruth: No conflict of interest Zharkov, Elena: No conflict of interest Broide, Efrat: No conflict of interest Assa, Amit: No conflict of interest Sigall-Boneh, Rotem: No conflict of interest Weiss, Batia: No conflict of interest Slae, Mordechai: No conflict of interest Dotan, Iris: No conflict of interest Godny, Lihi: No conflict of interest Kierkuś, Jarosław: No conflict of interest Griffiths, Anne: No conflict of interest Naftali, Timna: No conflict of interest Aloi, Marina: No conflict of interest Yerushalmy-Feler, Anat: No conflict of interest Schwerd, Tobias: No conflict of interest Reifen, Ram: No conflict of interest Turner, Dan: No conflict of interest

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P0951An exclusive whole-food Tasty&Healthy diet induces endoscopic and radiological healing in Crohn’s disease when used as maintenance treatment: results from the MyTasty clinical trial

Key Points

Abstract

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