What question did this study set out to answer?

This study aims to assess the effectiveness of exclusive enteral nutrition (EEN) in promoting biochemical and transmural healing in adults with Crohn's disease.

January 23, 2026Journal of Crohn s and Colitis

P0997Exclusive enteral nutrition induces early biochemical and transmural healing in adults with Crohn’s disease: Findings from the IMPLEMENT-CD study

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This study aims to assess the effectiveness of exclusive enteral nutrition (EEN) in promoting biochemical and transmural healing in adults with Crohn's disease.
Prospective, open-label cohort study design
Recruited adults with active Crohn's disease (CDAI ≥150)
Participants underwent 6 weeks of polymeric EEN under dietetic supervision
Eligibility assessed using clinical and ultrasound criteria
Evaluated outcomes included clinical, biochemical, and transmural markers.
38% of participants achieved the composite outcome of response or remission
In clinically active disease, 69% showed clinical response and 58% achieved remission
Biochemical response and remission were 35% and 12%, respectively
Transmural response was seen in 48% and healing in 12% of participants
Overall inflammatory markers improved significantly by week 6.

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Implication

Prospective cohort study evaluates exclusive enteral nutrition’s effect on healing in adults with Crohn’s disease, highlighting its efficacy.

Cite This Study

Chu et al. (2026) studied this question.

synapsesocial.com/papers/69731047c8125b09b0d1ffcc https://doi.org/10.1093/ecco-jcc/jjaf231.1178

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Implication

Prospective cohort study evaluates exclusive enteral nutrition’s effect on healing in adults with Crohn’s disease, highlighting its efficacy.

P0997Exclusive enteral nutrition induces early biochemical and transmural healing in adults with Crohn’s disease: Findings from the IMPLEMENT-CD study

Key Points

Discussion

Implication

Cite This Study

P0997Exclusive enteral nutrition induces early biochemical and transmural healing in adults with Crohn’s disease: Findings from the IMPLEMENT-CD study

Key Points

Discussion

Implication

Cite This Study

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