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This research assesses how well studies of enteral nutrition for Crohn's disease follow trial protocols and aims to recommend better practices.

P0643Advancing clinical trial methodology and reporting of outcomes for Exclusive Enteral Nutrition and Partial Enteral Nutrition in Crohn’s disease: Challenges and recommendations

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This research assesses how well studies of enteral nutrition for Crohn's disease follow trial protocols and aims to recommend better practices.
Searched electronic databases for interventional EEN and PEN trials in Crohn’s disease.
Appraised prospective studies for design, cohort definition, and intervention details.
Evaluated adherence assessment and treatment efficacy based on nutritional outcomes.
Observed significant heterogeneity among EEN/PEN trials.
Most studies were single-centred and underpowered.
Identified common methodological failings, including lack of control comparators and inadequate details on intervention efficacy.

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Evaluates methodological quality of enteral nutrition trials in Crohn’s disease, suggesting improvements for future research.

Melton et al. (2026) studied this question.

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