What question did this study set out to answer?

To examine the effects of gut microbiome changes from exclusive enteral nutrition on biologic treatment outcomes in pediatric Crohn's disease.

January 23, 2026Journal of Crohn s and Colitis

P1044EEN-Driven Microbiome Perturbation and Recovery: Associations with Biologic Timing, Dose Intensification, and Long-Term Outcomes in Pediatric Crohn’s Disease

View Full Paper

Ask AI

Bookmark

To examine the effects of gut microbiome changes from exclusive enteral nutrition on biologic treatment outcomes in pediatric Crohn's disease.
Prospective study with 48 children newly diagnosed with moderate to severe Crohn's disease.
Faecal samples were collected at five time points for gut microbiome analysis.
Clinical parameters were monitored throughout the study.
Patients achieved clinical remission after exclusive enteral nutrition.
Delayed initiation of infliximab correlated with greater microbial perturbation at week 8.
Better recovery of microbiome diversity linked to reduced need for dose intensification and improved long-term remission.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

This prospective study investigates how dietary treatment and biologic therapies impact microbiome and clinical outcomes in kids with Crohn's disease.

Cite This Study

Kwon et al. (2026) studied this question.

synapsesocial.com/papers/69730fc4c8125b09b0d1f761 https://doi.org/10.1093/ecco-jcc/jjaf231.1225

View Full Paper

Ask AI

Bookmark

Implication

This prospective study investigates how dietary treatment and biologic therapies impact microbiome and clinical outcomes in kids with Crohn's disease.

P1044EEN-Driven Microbiome Perturbation and Recovery: Associations with Biologic Timing, Dose Intensification, and Long-Term Outcomes in Pediatric Crohn’s Disease

Key Points

Discussion

Implication

Cite This Study

P1044EEN-Driven Microbiome Perturbation and Recovery: Associations with Biologic Timing, Dose Intensification, and Long-Term Outcomes in Pediatric Crohn’s Disease

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider