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Investigate molecular mechanisms underlying racial disparities in prostate cancer through integrated proteomic analysis.

January 23, 2026Cancer Research

Abstract B025: Integrated proteomic and molecular profiling reveals race-associated RNA splicing and metabolic reprogramming in prostate cancer

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Reveals race-specific molecular drivers of therapy-resistant prostate cancer in African American men, indicating critical target areas for treatment.

Investigate molecular mechanisms underlying racial disparities in prostate cancer through integrated proteomic analysis.
Conducted proteomic analysis using clinical samples from African American and Caucasian prostate cancer patients.
Applied multivariate statistical modeling to identify protein expression patterns.
Validated key protein targets with Western blotting and qPCR in specific cell lines.
Performed tissue immunohistochemistry and Raman lipid mapping to evaluate protein and lipid changes.
Identified distinct molecular profiles between African American and Caucasian prostate cancer tumors.
Observed upregulation of splicing regulators and metabolic enzymes in African American tissues.
Highlighted involvement of RNA splicing, mTOR signaling, and lipid composition in the disease.
Revealed increased levels of pro-tumorigenic lipids in African American tumors.

Guttula et al. (2026) studied this question.

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Reveals race-specific molecular drivers of therapy-resistant prostate cancer in African American men, indicating critical target areas for treatment.