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January 23, 2026Veterinary SciencesOpen Access

Multi-Omics Analysis Provides Insights into the Key Regulatory Pathways of Energy Metabolism in GIFT Under Salinity Stress

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Authors

YZYumeng ZhangDalian Ocean UniversityBCB. ChenNanjing Agricultural UniversityDLDayu LiNanjing Agricultural University

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Implication

Multi-omics analysis reveals metabolic reprogramming strategies in tilapia under salinity stress, indicating adaptation mechanisms.

Key Points

  • This study aims to uncover the molecular mechanisms of energy metabolism in tilapia when exposed to salinity stress.
  • Integrated transcriptomic and metabolomic approaches were utilized.
  • Freshwater (0‰) and brackish water (24‰) were used as control and experimental conditions.
  • Dynamic changes in gene expression and metabolite profiles were analyzed in liver tissues.
  • Differentially expressed genes and metabolites were identified and quantified.
  • Salinity stress significantly inhibited growth indicators like body weight and length.
  • A total of 1529 differentially expressed genes were recorded, with 399 up-regulated and 1130 down-regulated.
  • 127 significantly differential metabolites were identified.
  • Key pathways involving fatty acid biosynthesis and anabolic processes were suppressed.
  • Energy-sensing regulatory networks played a crucial role in metabolic reprogramming.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69730f34c8125b09b0d1ef9dhttps://doi.org/10.3390/vetsci13010105
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