What question did this study set out to answer?

To investigate gill responses of red tilapia to acute salinity stress and understand the underlying physiological mechanisms.

Integrated histopathological, physiological, biochemical, and molecular analysis of gill responses to acute salinity stress in red tilapia ( Oreochromis spp.)

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To investigate gill responses of red tilapia to acute salinity stress and understand the underlying physiological mechanisms.
Fish were exposed to saline water (17.7‰) for 192 hours with samples collected at multiple time points (0, 24, 48, 96, 192 h).
Conducted integrated histopathological, physiological, and molecular analyses using qRT-PCR.
Profiled biochemical changes, including antioxidant enzyme activity and ion levels.
Histopathological changes included lamellar shortening, thickening, and increased apoptotic index due to salinity stress.
Significant gene activation related to apoptosis, ABC transporters, and TLR signaling was observed during salinity exposure.
Dynamic biochemical responses showed early upregulation of osmoregulatory proteins followed by oxidative stress markers.

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Randomized trial investigates gill responses to acute salinity stress in red tilapia, indicating key physiological adaptations.

Saleh et al. (2026) studied this question.

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