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January 23, 2026JACC Case Reports1 citationsOpen Access

Heart Transplantation and Cancer Risk in a BRCA1 Breast Cancer Survivor

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LNLaura NotewareDuke Cancer InstituteEKEleanor KellerColumbia UniversityDLD. LotanNewYork–Presbyterian Hospital

Key Result

Personalized, multidisciplinary care is essential for optimizing outcomes in BRCA1 breast cancer survivors undergoing heart transplantation due to their high cancer risk.

Key Points

  • To explore the cancer risk associated with heart transplantation in survivors of BRCA1 breast cancer.
  • Analysis of cancer survivorship in BRCA1 carriers after heart transplantation
  • Assessment of multidisciplinary care approaches
  • Evaluation of personalized management strategies
  • Identified increased complexity in managing cancer risk post-transplant
  • Highlighted the necessity for tailored follow-up care
  • Emphasized the importance of multidisciplinary collaboration in treatment planning

Structured PICO

P
Population
BRCA1 breast cancer survivor undergoing heart transplantation
I
Intervention
Heart transplantation and post-transplant management

Highlights the need for multidisciplinary, personalized care in BRCA1 breast cancer survivors undergoing heart transplantation.

Abstract

Cancer survivorship in BRCA1 carriers adds complexity to post-transplant management. Multidisciplinary, personalized care is essential for optimizing outcomes in such high-risk patients.

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Cite This Study

Noteware et al. (2026) studied this question. Personalized, multidisciplinary care is essential for optimizing outcomes in BRCA1 breast cancer survivors undergoing heart transplantation due to their high cancer risk.

synapsesocial.com/papers/69730f9fc8125b09b0d1f677https://doi.org/10.1016/j.jaccas.2025.106608
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association2018 · 855 citations
  2. 2Long-Term Sirolimus for Primary Immunosuppression in Heart Transplant Recipients2018 · 119 citations
  3. 3Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline2022 · 298 citations
  4. 4Temporal Trends of De Novo Malignancy Development After Heart Transplantation2018 · 109 citations
  5. 5Effect of BRCA germline mutations on breast cancer prognosis2016 · 274 citations