What question did this study set out to answer?

The aim is to investigate how OCTN1 genotypes influence the clinical response to anti-TNFα treatment in ulcerative colitis patients.

January 23, 2026Journal of Crohn s and Colitis

P1318 The IBD-associated L503F variant of Organic Cation Transporter Novel (OCTN-)1 predicts a better response to antiTNFalpha in patients with ulcerative colitis: a single center analysis.

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Authors

PPPierluigi PucaUniversità Cattolica del Sacro Cuore LMLetizia MasiUniversità Cattolica del Sacro Cuore SPSimone ParelloUniversità Cattolica del Sacro Cuore

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Implication

Observational study shows OCTN1 L503F variant predicts better response to anti-TNFα in ulcerative colitis, suggesting genetic screening may guide therapy.

Key Points

The aim is to investigate how OCTN1 genotypes influence the clinical response to anti-TNFα treatment in ulcerative colitis patients.
Conducted a retrospective, single-center observational study
Enrolled adults diagnosed with ulcerative colitis starting anti-TNFα treatment
Collected clinical and endoscopic data at baseline and after 12 months
Patients genotyped for OCTN1 SNP 1050152 (c1672t)
22 patients were homozygous for the 503F variant, 49 heterozygous, and 34 wild-type
503F variant patients showed significantly higher steroid-free clinical remission rates (OR = 4.86)
Endoscopic improvement was greater in 503F variant patients (OR = 6.52)
Significant therapy persistence found for 503F variant (OR = 16.58)

Cite This Study

Puca et al. (2026) studied this question.

synapsesocial.com/papers/69731022c8125b09b0d1fe03 https://doi.org/10.1093/ecco-jcc/jjaf231.1499

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Implication

Observational study shows OCTN1 L503F variant predicts better response to anti-TNFα in ulcerative colitis, suggesting genetic screening may guide therapy.

P1318 The IBD-associated L503F variant of Organic Cation Transporter Novel (OCTN-)1 predicts a better response to antiTNFalpha in patients with ulcerative colitis: a single center analysis.

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Implication

Key Points

Cite This Study

P1318 The IBD-associated L503F variant of Organic Cation Transporter Novel (OCTN-)1 predicts a better response to antiTNFalpha in patients with ulcerative colitis: a single center analysis.

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Implication

Key Points

Cite This Study

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