What question did this study set out to answer?

The study aims to evaluate the impact of high-protein oral nutritional supplements containing HMB on muscle strength and nutritional status in patients with active Crohn's disease and sarcopenia.

January 23, 2026Journal of Crohn s and Colitis

P0816The effects of high-protein oral nutritional supplement containing HMB in active Crohn’s Patients complicated with sarcopenia: interim analysis of an open-label, randomized, controlled Pilot Study

View Full Paper

Ask AI

Bookmark

Authors

WFWenwen FuSun Yat-sen University XDX DengSun Yat-sen University QYQ Yang

Discussion

Member takes

Implication

An open-label, randomized, controlled pilot study shows improved muscle strength in Crohn’s patients with sarcopenia, suggesting effective nutritional intervention.

Key Points

The study aims to evaluate the impact of high-protein oral nutritional supplements containing HMB on muscle strength and nutritional status in patients with active Crohn's disease and sarcopenia.
Conducted an open-label, randomized, controlled pilot study.
Enrolled patients with active Crohn's disease and sarcopenia and assigned them to intervention and control groups.
The intervention group received enteral nutrition supplemented with a high-protein supplement containing HMB for 8 weeks.
EEN+ONS group showed a significant improvement in handgrip strength compared to the control group (22.15 kg vs. 19.85 kg).
A significant increase in skeletal muscle mass was observed in the intervention group (23.85 kg vs. 23.20 kg).
Bioelectrical impedance analysis revealed higher body cell mass and total body protein content in the EEN+ONS group (28.65 kg vs. 27.80 kg and 8.75 kg vs. 8.25 kg, respectively).
Nutritional status improved significantly in the intervention group with higher levels of albumin and hemoglobin, along with reduced CRP levels.

Cite This Study

Fu et al. (2026) studied this question.

synapsesocial.com/papers/69731022c8125b09b0d1fe83 https://doi.org/10.1093/ecco-jcc/jjaf231.997

View Full Paper

Ask AI

Bookmark

Implication

An open-label, randomized, controlled pilot study shows improved muscle strength in Crohn’s patients with sarcopenia, suggesting effective nutritional intervention.

P0816The effects of high-protein oral nutritional supplement containing HMB in active Crohn’s Patients complicated with sarcopenia: interim analysis of an open-label, randomized, controlled Pilot Study

Discussion

Member takes

Implication

Key Points

Cite This Study

P0816The effects of high-protein oral nutritional supplement containing HMB in active Crohn’s Patients complicated with sarcopenia: interim analysis of an open-label, randomized, controlled Pilot Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider