What question did this study set out to answer?

To analyze the fungal microbiota profile in Chilean patients with ulcerative colitis and compare it to healthy controls.

P1329 Fungal Microbiota Profile in Chilean Ulcerative Colitis: Yarrowia, Filobasidium, and Penicillium — New Kids on the Block?

View Full Paper

Ask AI

Bookmark

To analyze the fungal microbiota profile in Chilean patients with ulcerative colitis and compare it to healthy controls.
Sample collection from intestinal mucosal washes of 101 participants
Sequencing of ITS1/ITS2 regions for fungal profiling
Assessment of alpha diversity using Chao1 and Shannon indices
Evaluation of beta diversity through Unweighted UniFrac and PERMANOVA
Differential abundance analyses and bulk RNA-seq correlation with gene expression
Fungal richness was significantly lower in ulcerative colitis patients than in controls
Significant changes in beta diversity detected through Unweighted UniFrac
A decreased Ascomycota/Basidiomycota ratio was observed in ulcerative colitis
Changes in specific genera included decreased Yarrowia and Filobasidium, with increased Rhodotorula araucariae and Penicillium penicilloides
Certain species correlated positively with inflammatory gene expression, indicating potential roles in mucosal inflammation.

Authors

No takes yet. Share an insight, caveat, or question.

This analysis characterizes fungal microbiota differences in Chilean ulcerative colitis and highlights their immunological implications.

Pérez et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark