What question did this study set out to answer?

To review the biological mechanisms underlying cancer immune evasion and summarize emerging therapeutic interventions aimed at promoting tumor rejection.

April 5, 2015Seminars in Cancer BiologyOpen Access

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

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Authors

DVDass S. VinayTulane University ERElizabeth P. RyanColorado State University GPGraham PawelecNational Institutes of Health

Discussion

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Implication

Narrative review uncovers mechanisms of tumor immune escape, highlighting potential immunotherapies and natural phytochemicals to enhance tumor rejection.

Key Points

To review the biological mechanisms underlying cancer immune evasion and summarize emerging therapeutic interventions aimed at promoting tumor rejection.
Narrative synthesis of cellular and molecular pathways involved in tumor immune escape.
Evaluation of therapeutic targets designed to counteract immune evasion, including immunomodulators and plant-derived compounds.
Tumors evade host surveillance through immunoediting, dormancy via equilibrium and senescence, impaired antigen presentation, and regulatory T cell-mediated immunosuppression.
Anticancer strategies promoting T helper 1, natural killer cell, and gamma-delta T cell responses, along with interleukin-12 induction, demonstrate effectiveness in countering tumor progression.
Bioactive phytochemicals and plant- or mushroom-derived polysaccharides counter tumor-induced genetic instability, dysregulated metabolism, and proliferative signaling.

Cite This Study

Vinay et al. (2015) studied this question.

synapsesocial.com/papers/69737b5691d82d0935e49978 https://doi.org/10.1016/j.semcancer.2015.03.004

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April 5, 2015Seminars in Cancer BiologyOpen Access

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

View Full Paper

Ask AI

Bookmark

Authors

DVDass S. VinayTulane University ERElizabeth P. RyanColorado State University GPGraham PawelecNational Institutes of Health

Discussion

Member takes

Implication

Narrative review uncovers mechanisms of tumor immune escape, highlighting potential immunotherapies and natural phytochemicals to enhance tumor rejection.

Key Points

To review the biological mechanisms underlying cancer immune evasion and summarize emerging therapeutic interventions aimed at promoting tumor rejection.
Narrative synthesis of cellular and molecular pathways involved in tumor immune escape.
Evaluation of therapeutic targets designed to counteract immune evasion, including immunomodulators and plant-derived compounds.
Tumors evade host surveillance through immunoediting, dormancy via equilibrium and senescence, impaired antigen presentation, and regulatory T cell-mediated immunosuppression.
Anticancer strategies promoting T helper 1, natural killer cell, and gamma-delta T cell responses, along with interleukin-12 induction, demonstrate effectiveness in countering tumor progression.
Bioactive phytochemicals and plant- or mushroom-derived polysaccharides counter tumor-induced genetic instability, dysregulated metabolism, and proliferative signaling.

Cite This Study

Vinay et al. (2015) studied this question.

synapsesocial.com/papers/69737b5691d82d0935e49978 https://doi.org/10.1016/j.semcancer.2015.03.004

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