Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 5, 2013Molecular & Cellular ProteomicsOpen Access

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

View Full Paper
Ask AI
Bookmark
Share

Authors

LFLinn FagerbergScience for Life LaboratoryBHBjörn M. HallströmUniversity of CopenhagenPOPer OksvoldScience for Life Laboratory

Discussion

Loading...

Member takes

Implication

Analyzes tissue-specific gene expression in humans, indicating a valuable resource for exploring human biology.

Key Points

  • To classify tissue-specific expression patterns of human genes for all major organs and tissues.
  • Conducted quantitative transcriptomics analysis using RNA-Seq.
  • Combined RNA expression data with antibody-based proteomics analysis.
  • Launched an updated Human Protein Atlas integrating RNA and protein data for ∼80% of human genes.
  • Developed a comprehensive classification of human protein-coding genes based on tissue-specificity.
  • Presented a molecular expression map for exploring human biology and disease.

Cite This Study

Fagerberg et al. (2013) studied this question.

synapsesocial.com/papers/6973844b05df43890e1d1a41https://doi.org/10.1074/mcp.m113.035600
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TopHat: discovering splice junctions with RNA-Seq2009 · 12,267 citations
  2. 2Unique Chromatin Remodeling and Transcriptional Regulation in Spermatogenesis2002 · 490 citations
  3. 3BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources2009 · 1,406 citations
  4. 4Ensembl 20132012 · 902 citations
  5. 5The Human Protein Atlas—a tool for pathology2008 · 1,199 citations