What question did this study set out to answer?

To measure and compare urine concentrations of tobacco-related toxicant biomarkers across exclusive e-cigarette users, combustible cigarette smokers, dual users, and never tobacco users.

December 14, 2018JAMA Network OpenOpen Access

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

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Authors

MGMaciej Ł. GoniewiczRoswell Park Comprehensive Cancer Center DSDanielle M. SmithRoswell Park Comprehensive Cancer Center KEKathryn C. EdwardsWestat (United States)

Discussion

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Implication

Cohort study demonstrates lower toxicant exposure in exclusive electronic cigarette users versus smokers, suggesting substantial harm reduction compared with combustible tobacco.

Key Points

To measure and compare urine concentrations of tobacco-related toxicant biomarkers across exclusive e-cigarette users, combustible cigarette smokers, dual users, and never tobacco users.
Conducted a cross-sectional biomarker evaluation using data from the population-based Population Assessment of Tobacco and Health (PATH) longitudinal cohort study in the United States (N = 5105).
Classified adult participants into exclusive e-cigarette users (n = 247), exclusive cigarette smokers (n = 2411), dual users (n = 792), and never tobacco users (n = 1655).
Assayed geometric mean concentrations of 50 biomarkers spanning nicotine, tobacco-specific nitrosamines (TSNAs), metals, polycyclic aromatic hydrocarbons (PAHs), and volatile organic compounds (VOCs).
Exclusive e-cigarette users had 10% to 98% significantly lower concentrations of biomarkers for TSNAs, PAHs, most VOCs, and nicotine compared with exclusive combustible cigarette smokers, though metal levels and 3 VOCs remained comparable.
Never tobacco users exhibited 19% to 81% significantly lower concentrations of biomarkers for nicotine, TSNAs, specific metals (including cadmium and lead), and select VOCs (including acrylonitrile) compared with exclusive e-cigarette users.
Exclusive cigarette smokers had 10% to 36% lower concentrations of several toxicant biomarkers than dual users, with cigarette smoking frequency among dual users positively correlating with overall toxicant and nicotine exposure.

Cite This Study

Goniewicz et al. (2018) studied this question.

synapsesocial.com/papers/6973af0a225cce4472e38d33 https://doi.org/10.1001/jamanetworkopen.2018.5937

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Implication

Cohort study demonstrates lower toxicant exposure in exclusive electronic cigarette users versus smokers, suggesting substantial harm reduction compared with combustible tobacco.

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

Discussion

Member takes

Implication

Key Points

Cite This Study

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