Cross-sectional analysis reveals frailty links to cognitive performance in those with preclinical Alzheimer's, indicating the need for further study.
In a cohort screened for a preclinical AD trial, elevated Aβ levels were associated with frailty and frailty was associated with reduced cognitive performance independent of elevated Aβ levels. These associations, and whether or not frailty is associated with longitudinal cognitive decline independent of Aβ status, warrant further study.
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Huynh et al. (2026) studied this question.
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