What question did this study set out to answer?

To examine the longitudinal relationship between frailty trajectories and the development of mild cognitive impairment and Alzheimer's dementia while accounting for postmortem neuropathological burden.

December 1, 2021Aging MedicineOpen Access

10‐year frailty trajectory is associated with Alzheimer’s dementia after considering neuropathological burden

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Authors

LWLindsay WallaceDalhousie University OTOlga TheouMinistry of Health JGJudith GodinDalhousie University

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Implication

Cohort study reveals faster frailty progression predicts dementia in older adults beyond neuropathology, highlighting systemic health as a key target for dementia prevention.

Key Points

To examine the longitudinal relationship between frailty trajectories and the development of mild cognitive impairment and Alzheimer's dementia while accounting for postmortem neuropathological burden.
Assessed 625 older adults (67.5% female, baseline age 83.2 ± 5.9 years) with annual clinical evaluations over an average follow-up of 5.6 ± 3.7 years until death and postmortem neuropathologic examination.
Calculated an annual frailty index based on 41 health variables and modeled trajectories using mixed effects models adjusted for age, sex, education, and a 10-item neuropathological burden index.
Determined diagnoses of mild cognitive impairment (MCI) and dementia through postmortem review of clinical data blinded to neuropathological findings.
The baseline frailty index averaged 0.24 ± 0.12 and increased longitudinally at a rate of 0.026 per year (approximately one deficit per year).
Prior to death, 27.7% of participants were diagnosed with MCI and 38.6% were diagnosed with dementia.
Frailty trajectories were significantly steeper in participants clinically diagnosed with cognitive impairment prior to death, persisting after adjustment for age, sex, education, and neuropathological index.

Cite This Study

Wallace et al. (2021) studied this question.

synapsesocial.com/papers/6a71193cfebe604dd709d022 https://doi.org/10.1002/agm2.12187

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Implication

Cohort study reveals faster frailty progression predicts dementia in older adults beyond neuropathology, highlighting systemic health as a key target for dementia prevention.

10‐year frailty trajectory is associated with Alzheimer’s dementia after considering neuropathological burden

Discussion

Member takes

Implication

Key Points

Cite This Study

10‐year frailty trajectory is associated with Alzheimer’s dementia after considering neuropathological burden

Discussion

Member takes

Implication

Key Points

Cite This Study

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