Key result
Cardiac rehab and nutritional interventions mitigate frailty, sarcopenia, and malnutrition in older adults with HFpEF.
Why the study?
HFpEF is the most common heart failure phenotype in older adults, and increasing evidence indicates it is a systemic, age-related syndrome involving frailty, sarcopenia, and malnutrition rather than an isolated cardiac disease.
Do exercise-based cardiac rehabilitation and nutritional interventions improve frailty, sarcopenia, malnutrition, and clinical outcomes in older adults with HFpEF?
Do exercise-based cardiac rehabilitation and nutritional interventions improve frailty, sarcopenia, malnutrition, and clinical outcomes in older adults with HFpEF?
This narrative review highlights that HFpEF in older adults is a systemic geriatric syndrome intertwined with frailty, sarcopenia, and malnutrition, which can be effectively targeted through integrated exercise-based cardiac rehabilitation and nutritional support.
Answers are grounded in this paper and cite their sources.
May support combined rehab-nutrition strategies in frail HFpEF; leaves open confirmation in prospective trials.
Heart failure with preserved ejection fraction (HFpEF) is the most common heart failure phenotype in older adults, associated with significant functional impairment and poor prognosis. Increasing evidence suggests that HFpEF should be considered a systemic, age‐related syndrome, rather than an isolated cardiac disease. This review summarizes recent advances in the epidemiology, pathophysiology, and cellular mechanisms of HFpEF, with a particular focus on the frailty–sarcopenia–malnutrition triad. Age‐related inflammation, mitochondrial dysfunction, and anabolism resistance interact with the hemodynamic abnormalities specific to HFpEF, leading to decreased exercise tolerance and functional decline. Frailty, muscle loss, and malnutrition often coexist in elderly patients with HFpEF and synergistically exacerbate clinical outcomes. Exercise‐based cardiac rehabilitation and narrative lifestyle interventions are effective strategies for addressing these geriatric syndromes, and this review will address these issues. This article is a narrative review synthesizing current evidence on geriatric vulnerability phenotypes and rehabilitation‐based interventions in older adults with HFpEF.
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Li et al. (2026) conducted a review in Heart failure with preserved ejection fraction (HFpEF) in older adults. Exercise-based cardiac rehabilitation and nutritional interventions was evaluated. Exercise-based cardiac rehabilitation and nutritional interventions mitigate frailty, sarcopenia, and malnutrition in older adults with HFpEF.
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