Why the study?
Understanding of HFpEF pathophysiology remains incomplete, drug development has been challenging, and no universally accepted therapies alter its clinical course.
Design
Review
Key result
Heart failure with preserved ejection fraction is a complex, systemic geriatric syndrome involving multiple organ systems, for which there are currently no universally accepted disease-modifying therapies.
Authors
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Shifts HFpEF care toward holistic geriatric assessment; leaves open targeted disease-modifying therapies.
This review highlights the paradigm shift in understanding HFpEF from an isolated diastolic dysfunction to a complex, systemic geriatric syndrome, emphasizing the need for novel therapeutic approaches.
Upadhya et al. (2019) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Heart failure with preserved ejection fraction is a complex, systemic geriatric syndrome involving multiple organ systems, for which there are currently no universally accepted disease-modifying therapies.