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January 24, 2026MicrobiologyOpenOpen Access

Differentiating Damp‐Heat and Cold‐Damp Diarrhea in Rat Models via Gut Microbiota Dysbiosis and Short‐Chain Fatty Acid Profiling

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Authors

HZHao ZhangXSXia SongWMWenwen Mi

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Overview

Differentiates intestinal conditions in rats, showing distinct biomarkers and treatment effects for each diarrhea type.

Key Points

  • The study aims to identify biomarkers that differentiate between damp-heat diarrhea and cold-damp diarrhea using gut microbiota and short-chain fatty acid profiles.
  • Established rat models for damp-heat and cold-damp diarrhea.
  • Measured changes in weight, temperature, food intake, water consumption, and diarrhea index.
  • Employed ELISA for inflammatory markers and histological evaluations for structural changes.
  • Used GC-MS for SCFA content analysis and 16S rRNA sequencing for microbiota composition analysis.
  • Conducted differential analysis to compare SCFA profiles and gut microbiota between groups.
  • Significant decrease in body weight and food intake in induced models over time.
  • Histopathological damage indicated by elevated inflammatory markers and reduced tight junction protein expression.
  • Notable differences in Lachnoclostridium and Marvinbryantia abundance between damp-heat and cold-damp groups.
  • Potential for mucosal color assessment as a diagnostic tool for clinical practice.
  • Lachnoclostridium and Marvinbryantia identified as potential biomarkers, requiring further validation.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69746187bb9d90c67120b69chttps://doi.org/10.1002/mbo3.70164
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