What question did this study set out to answer?

The study aims to determine the optimal lymph node count for adequate colorectal cancer management.

January 25, 2026Surgical Laparoscopy Endoscopy & Percutaneous Techniques0 citations

Optimal Lymph Node Count for Colorectal Cancer Surgery: A Cohort Study Utilizing Real-World Data

XSXu SunNankai University XLX. Q. LiUniversity Health Network WZWen Zhao

Key Points

The study aims to determine the optimal lymph node count for adequate colorectal cancer management.
Retrospective analysis of 4429 colorectal cancer patients from January 2018 to December 2023.
Developed a statistical model using the β-binomial distribution and maximum likelihood method.
Analyzed lymph node counts associated with false-negative probabilities in colon and rectal cancer.
For colon cancer, 7 LNs for pT1 and 11 LNs for pT2 yield a <5% false-negative probability.
For pT3 and pT4 colon cancers, 16 and 20 LNs were needed, respectively, to keep false-negatives below 10%.
For rectal cancer, 7 LNs for pT1 and 12 LNs for pT2 also resulted in a <5% false-negative probability.
For pT3 and pT4 rectal cancers, 15 and 19 LNs needed to be removed to maintain a <10% false-negative rate.

Abstract

Background: Colorectal cancer is a leading global malignant tumor, and adequate lymph node (LN) examination is essential for its management. Methods: This retrospective study, conducted from January 2018 to December 2023 at the First Medical Center of the Chinese PLA General Hospital, aimed to develop a statistical model for assessing LN count adequacy. To calculate false-negative probabilities, a new statistical model based on the β-binomial distribution and maximum likelihood method in R software was used. Results: Among 4429 screened colorectal cancer patients, there were 2314 with colon cancer and 2115 with rectal cancer. For colon cancer, the excision of 7 LNs for pT1 and 11 LNs for pT2 was associated with a likelihood of encountering occult positive LNs remained below 5%. For pT3 and pT4, after the removal of 16 LNs and 20 LNs, respectively, the likelihood of overlooking a positive node was below 10%. For rectal cancer, the excision of 7 LNs for pT1 and 12 LNs for pT2 was associated with a likelihood of encountering occult positive LNs remained below 5%. For pT3 and pT4, after removing 15 LNs and 19 LNs, the likelihood of overlooking a positive node was below 10%. Conclusions: Our study establishes a novel quantitative framework that links LN harvest thresholds to the risk of false-negative metastasis in colorectal cancer, supporting adopting a more personalized approach.

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