Key result
Remnant cholesterol and LDL-C discordance linked to increased risk of diabetes, microvascular disease, and CVD.
Why the study?
Does the discordance between remnant cholesterol and LDL-c predict diabetes, diabetic microvascular diseases, and cardiovascular disease?
Does the discordance between remnant cholesterol and LDL-c predict diabetes, diabetic microvascular diseases, and cardiovascular disease?
Discordance between remnant cholesterol and LDL-c serves as a significant predictor for diabetes, diabetic microvascular complications, and cardiovascular disease, particularly in individuals with hypertension or insulin resistance.
Answers are grounded in this paper and cite their sources.
May aid risk stratification in diabetes and CVD; leaves open causality and need for prospective trials.
(1)The discordance between RC and LDL-c is significantly associated with diabetes, diabetic microvascular diseases, and cardiovascular disease.(2) In NHANES, the RCS analysis showed linear relationships for diabetes, DKD, DR and CVD. In clinical cohort, the RCS analysis showed linear relationships for diabetes and non-linear for CVD.(3)The association of discordance with diabetes, DKD and CVD was more prevalent in individuals with hypertension and HOMA-IR ≥3.1, while individuals with hypertension were more sensitive to DR and individuals with HOMA-β <100 were more sensitive to diabetes.(4)The discordance showed the certain predictive ability for all outcomes.
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Wang et al. (2026) studied this question. Discordance between remnant cholesterol and LDL cholesterol is significantly associated with increased risk of diabetes, diabetic microvascular diseases, and cardiovascular disease.
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